Effect of puerarin on myocardial perfusion and ventricular wall motion in patients with acute coronary syndrome
- Author:
Ling NIU
;
Dongye LI
;
Yong XIA
;
Defeng PAN
;
Xiaoping WANG
;
Yan YAN
;
Li LIANG
;
Tongda XU
- Publication Type:Journal Article
- Keywords:
acute coronary syndrome;
myocardial perfusion index;
ventricular wall motion index;
puerarin
- From:
Journal of Geriatric Cardiology
2008;5(3):155-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of puerarin(Pur)on myocardial perfusion and ventricular wall motion in patients withacute coronary syndrome(ACS).Methods Thirty-seven patients with ACS were randomly divided into two groups:conventionaltreatment group(n=17,11 males,range of age:32-80 years,average age:60.9±4.9 years)and Purtreatment group(n=20,12 males,rangeof age:40-76 years.average age:62.7±3.5 years).Patients in the conventional treatment group received standard treatment according tothe current guidelines,while patients in the Pur treatment group received intravenous administration of Pur(500 mg/day)for 10 daysplus conventional treatment.Real-time myocardial contrast echocardiography (RT-MCE) was performed to evaluate the change inmyocardial perfusion index (MPI)and veiltricular wall motion index(VWMI)at admission and 10 days after treatment.Results At10 days after treatment,MPI was significantly higher(P＜0.01)and VWMI significantly lower(P＜0.01)in the Pur group comparingwith those in the conventional group.Conclusions Puerarin might improve myocardial microcirculation perfusion and ventricularwall motion in patients with ACS.
