Prognostic significance of international prognostic index(IPI) in peripheral T-cell lymphoma, not otherwise specified
10.3760/cma.j.issn.1009-9921.2009.10.008
- VernacularTitle:国际预后指数在外周T细胞淋巴瘤-非特异型预后判断中的意义
- Author:
Yinan WANG
;
Hongmin LI
;
Shoudong MA
;
Yu ZHAO
;
Weidong LIU
;
Haishu YUE
- Publication Type:Journal Article
- Keywords:
T-cell lymphoma non otherwise specified;
International prognostic index;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2009;18(10):603-605
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the international prognostic index (IPI) in peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Methods From May 2005 to May 2008, 75 patients of PTCL--NOS were reviewed. All the patients were diagnosed again by immunohistochemical staining. According to IPI, they were divided into four groups:low risk (0-1), intermediate-low(2), intermediate-high(3), high risk (4-5), then the difference of treatment effectiveness and prognosis among them were analysed. Results IPI scoring of 75 patients were classified as low risk , 10 (13.3%); as intermediate-low, 14 (18.7%); as intermediate-high, 28 (37.3 %); as high risk, 23 (30.7%). There was a significant difference in complete remission rates with first line treatment(X2=16.677,P=0.001), and overall survival rates (P=0.0000) among four groups. Median survival time among 4 groups were 36+, 29.00, 17.00, 10.00 months. 1-year OS were 100.00 %, 89.05 %, 64.24 %, 15.73 %; 2-year OS were: 75.00 %, 53.01%, 34.42 %, 2.00 % respectively. Multivariate analysis showed that both complete remission rates of first line treatment(P=0.002) and IPI(P = 0.049) were independent prognostic factor for PTCL-NOS, while single index of IPI was not. Conclusion At a certain extent, IPI model was able to predict response of treatment effective and prognosis in PTCL-NOS.
