Sex hormone levels may be an important factor influencing the gender dimorphism in prognosis of severe trauma patients
10.3760/cma.j.issn.1671-0282.2015.03.016
- VernacularTitle:性激素水平可能是严重创伤患者预后性别差异的重要影响因素
- Author:
Kaichao YANG
;
Lei GENG
;
Xiaoguang ZHU
;
Liu RONG
;
Wei WU
;
Gang ZHAO
;
Qiming FENG
- Publication Type:Journal Article
- Keywords:
Trauma;
Sex hormone;
Injury severity;
Age;
Hospitalized mortality
- From:
Chinese Journal of Emergency Medicine
2015;24(3):304-309
- CountryChina
- Language:Chinese
-
Abstract:
Objective To describe the association between age and the sex-based outcome difference and analyze the potential mechanism responsible for sex-based outcome difference in severe trauma patients.Methods A retrospective analysis derived from the Emergency Intensive Care Unit of the acute trauma center of the Shanghai Municipal Sixth People's Hospital during the 2010-2013 period was performed to identify sex-based outcome differences after severe blunt trauma.The study cohort of patients was then stratified by age:(1) 18 years ≤ age ＜45 years,(2) 45 years ≤ age ≤ 55 years,and (3) age ＞55 years.Crude and adjusted odds ratios (ORs) were calculated to evaluate the association between gender and the hospitalized mortality,both overall and subgroups according to age categories.Results A total of 987 severe trauma patients met our inclusion criteria were enrolled in this study.Crude mortality was higher in male severe trauma patients (male 9.1％ vs.female 5.0％,P ＜ 0.05).Multiple logistic regression revealed that females had a 79％ decrease in hospitalized mortality compared with males (OR =0.21,95％ CI:0.07-0.64,P =0.006).This difference was most distinct in patients with age ＜ 45 years,(OR =0.15,95％ CI:0.04-0.67,P =0.012).There is no significant difference between genders in mortality of trauma patients with 45 years ≤ age ≤ 55 years and age ＞ 55 years.Conclusions The present study revealed a statistical significant association between gender and mortality among severe blunt trauma patients,particularly in patients with age ＜ 45 years.These results may highlight the importance of sex hormones in outcomes of severe trauma.
