Relationship of insulin resistance with serum 25-hydroxyvitamin D levels and arterial stiffness in elderly patients
10.3760/cma.j.issn.0254-9026.2015.03.007
- VernacularTitle:老年患者胰岛素抵抗与维生素D水平及动脉僵硬度的关系
- Author:
Jing CHANG
;
Yuanping HOU
;
Shengli LI
;
Jing YE
;
Jinling WU
;
Qianmei SUN
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
Vitamin D deficiency;
Arteriosclerosis
- From:
Chinese Journal of Geriatrics
2015;34(3):253-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of insulin resistance with serum 25-hydroxyvitamin D levels and arterial stiffness in elderly patients.Methods A total of 162 elderly inpatients (aged 60 years or over) were recruited from 2012 to 2014.Levels of fasting serum insulin,fasting serum glucose,creatinine and vitamin D were determined.Insulin resistance (IR) was evaluated by the homeostasis model assessment of insulin resistance (HOMA-IR).The patients were divided into the following three groups according to HOMA-IR:the low IR group with HOMA-IR less than 2 (n=78),the median IR group with HOMA-IR between 2 and 6 (n=43),and the high IR group with HOMA-IR greater than 6 (n=41).Arterial stiffness was assessed by carotid-femoral pulse wave velocity (cfPWV).Arterial stiffness and serum vitamin D levels were compared among the three groups.Results cfPWV was increased and the serum 25-hydroxyvitamin D level was decreased in the high insulin resistance group compared with the low insulin resistance group[(13.2± 5.7) μg/L vs.(17.8±6.2) μg/L,(14.3±5.2) m/s vs.(11.9±3.0) m/s].Multiple liner regression analysis showed that IR was negatively correlated with the serum 25 hydroxyvitamin D level (r=-0.63,P＜0.05) and positively correlated with arterial stiffness (r=0.45,P＜0.05) after adjustment for age,sex and other confounders.Conclusions Elderly patients with high insulin resistance may have lower levels of serum vitamin D and higher arterial stiffness.
