Effects Of Chitosan On Human Osteoblasts.
- Author:
Ki Hong KIM
1
;
Young Ju PARK
;
Jun Woo PARK
;
Yong Chan LEE
;
Byoung Ouck CHO
;
Byoung Keun AHN
Author Information
1. Department of Oral & Maxillofacial Surgery, College of Medicine, Hallym University, Korea.
- Publication Type:Original Article
- Keywords:
Osteoblast;
Chitosan;
BMP-2
- MeSH:
Bone Morphogenetic Protein 7;
Chitosan*;
Humans*;
Osteoblasts*;
Osteocalcin
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2002;28(4):280-285
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
As the result of the study concerning "bone inducibility of chitosan", 1. "BMP-2"was observed mainly through the test when the "osteoblast"is exposed to the "chitosan". The expression of BMP-2 was 542.63 times compared to control after 2 hours exposure and it was maintained 16.60 times till 24 hours. 2. The expression of BMP-4 was decreased compared to control during exposure. 3. The expression of BMP-7 revealed two peaks during exposure. 4. The expression of osteocalcin was increased in early phase, and then decreased. Although it is not clear whether the "chitosan"is clinically effective material as a "bone induction material", we could say that it has a function for bone induction. Further detailed study will be required.
