Pregabalin combined with intrathecal sufentanil infusion for breakthrough pain in patients with bone metastases
10.11817/j.issn.1672-7347.2014.04.011
- VernacularTitle:普瑞巴林联合鞘内输注舒芬太尼治疗骨转移癌爆发痛的临床研究
- Author:
Qiwang CAO
;
Dong HUANG
;
Huiqiao XU
;
Liping WU
;
Sihan GU
- Publication Type:Journal Article
- Keywords:
pregabalin;
sufentanil;
intrathecal;
infusion;
breakthrough pain;
background pain
- From:
Journal of Central South University(Medical Sciences)
2014;(4):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To evaluate the analgesic effect of pregabalin combined with intrathecal sufentanil infusion for the treatment of breakthrough pain in patients with bone metastases. Methods: A total of 60 breakthrough pain patients with bone metastases were randomly divided to 3 groups: group A (pregabalin combined with intrathecal sufentanil infusion group,n=20), group B (placebo combined with intrathecal sufentanil infusion group,n=20) and group C (oral morphine sulfate controlled-release tablet group,n=20). The differences in visual analogue scale (VAS)between background pain and breakthrough pain, the seizure frequency of breakthrough pain, general satisfaction and side effects of the 3 groups were observed. Results: hTe seizure frequency and VAS of breakthrough pain in group A decreased signiifcantly after the treatment (P<0.05) and the general satisfaction was the best among the the 3 groups (P<0.05), with less nausea and vomiting, constipation, drowsiness and fewer other side effects. Conclusion: Pregabalin combined with intrathecal sufentanil infusion can effectively relieve breakthrough pain in patients with bone metastases.
