Clinical analysis of bcr-abl fusion gene positive children with acute lymphoblastic leukemia
10.3760/cma.j.issn.1009-9921.2014.03.009
- VernacularTitle:bcr-abl融合基因阳性儿童急性淋巴细胞白血病临床分析
- Author:
Ai ZHANG
;
Qun HU
;
Liuqing ZHANG
;
Shuangyou LIU
;
Aiguo LIU
;
Xiaoling ZHANG
;
Yaqin WANG
- Publication Type:Journal Article
- Keywords:
Leukemia,lymphocytic,acute;
Fusion proteins,bcr-abl;
Child;
Prognosis
- From:
Journal of Leukemia & Lymphoma
2014;23(3):160-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical features of pediatric patients with acute lymphoblastic leukemia(ALL) with bcr-abl fusion gene transcript,and discuss the treatment,prognosis factors of this kind of ALL.Methods Clinical features,treatment and prognosis were studied retrospectively in 7 bcr-abl fusion gene positive ALL patients.bcr-abl fusion gene was detected by reverse transcription polymerase chain reaction (RT-PCR).Results The average age of the 7 patients was 8 years and 1 month old.All of them were common B-immunology ALL.The rate of complete response was 50 ％ after 33 days' treatment.Conclusions The incidence rate of bcr-abl fusion gene positive ALL in pediatric is low.This type of ALL has poor remission,high relapse rate and poor prognosis.
