Significance of 18F-FDG PET-CT in monitoring early chemotherapy response in patients with diffuse large B-cell lymphoma
10.3760/cma.j.issn.1009-9921.2014.06.009
- VernacularTitle:18F-FDG PET-CT在评价弥漫大B细胞淋巴瘤早期化疗反应中的应用价值
- Author:
Ling YUAN
;
Liping SU
;
Yuping ZHENG
;
Jie CUI
;
Zhongtai ZHANG
;
Ming ZHAO
- Publication Type:Journal Article
- Keywords:
Lymphoma,large B-cell,diffuse;
18F-FDG;
Positron-emission tomography
- From:
Journal of Leukemia & Lymphoma
2014;23(6):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the value of 18F-FDG PET-CT in monitoring early chemotherapy response in patients with diffuse large B-cell lymphoma (DLBCL).Methods 56 patients with DLBCL received 18F-FDG PET-CT before and after 2 cycles of chemotherapy (CHOP or R-CHOP protocol).The patients were divided into 3 groups,including complete response group (30 cases),partial response group (18 cases) and no response group (8 cases).The x2 test was performed on comparison of complete remission rate and the t test on SUVmax.Results Complete remission rate of complete response group,partial response group and no response group were 93.33 ％ (28/30),66.67 ％ (12/18),and 12.50 ％ (1/8),respectively (x2 =21.62,P ＜ 0.005).Complete remission rate of complete response group was higher than that of partial response group (x 2 =4.00,P ＜ 0.05).Complete remission rates of complete response group and partial response group were higher than that of no response group (x2 =18.58,P ＜ 0.005; x2 =4.51,P ＜ 0.05).A significant difference was observed in SUVmax of partial response group before and after chemotherapy (17.18±4.68 vs 5.20±3.35,t =14.32,P ＜ 0.001) and no obvious difference was showed in SUVmax of no response group between before and after chemotherapy (16.63±6.49 vs 13.81±5.95,t =2.073 2,P ＞ 0.05).Conclusion 18F-FDG PET-CT is very useful and helpful for predicting early chemotherapy response in DLBCL.
