Effectiveness of 90Sr-90Y applicator combined with topical timolol maleate treatment for infantile superficial hemangiomas
10.3760/cma.j.issn.2095-2848.2014.06.011
- VernacularTitle:90Sr-90Y敷贴联合噻吗洛尔局部外涂治疗婴幼儿浅表血管瘤的疗效观察
- Author:
Hongjian ZHU
;
Qinghong LIU
;
Yanxing GUAN
- Publication Type:Journal Article
- Keywords:
Hemangioma;
Infant;
Timolol;
Brachytherapy;
Strontium radioisotopes;
Yttrium radioisotopes
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2014;34(6):466-469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy and safety of 90Sr-90Y applicator combined with topical timolol maleate for infantile superficial hemangiomas.Methods A total of 59 infants with hemangiomas were randomly divided into a study group (n=33; ≤3 months,15 cases;＞3 months,18 cases) and a control group (n=26; ≤3 months,10 cases; ＞3 months,16 cases).The study group was treated with 90Sr-90Y applicator combined with timolol maleate solution (0.5％) and the control group was treated with the same dose of 90Sr-90Y applicator combined with saline.Treatment effectiveness was compared between the two groups,and x2 test was used for statistical analysis.Adverse reaction was observed and recorded.Results The effective rate was 18/18,and the cure rates were 14/15 (≤ 3 months) and 16/18 (＞3 months) in the study group.The effective rates were 8/10 (≤3 months) and 11/16 (＞3 months),and the cure rates were 6/10 (≤3 months) and 9/16 (＞3 months) in the control group.Both the effective rate and cure rate of the study group were significantly higher than those of control group (x2 =22.22 and 30.29,≤3 months; x2 =36.69 and 27.31,＞3 months; all P＜0.01).Significant adverse reaction was not found in both groups.Conclusion 90Sr-90Y applicator combined with 0.5％ solution of topical timolol maleate has a very high effective and cure rate for infantile superficial hemangiomas,without significant adverse reaction observed.
