The expression and significance of KLK9 in liver cancer
10.3760/cma.j.issn.1007-8118.2015.03.003
- VernacularTitle:激肽释放酶9基因在原发性肝癌中的表达及临床意义
- Author:
Xuefeng RAO
;
Hong CAO
;
Jingliang WU
;
Xiaohua ZHU
;
Chuanwen LIAO
- Publication Type:Journal Article
- Keywords:
Kallikrein 9;
Gene;
Liver cancer
- From:
Chinese Journal of Hepatobiliary Surgery
2015;21(3):156-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of kallikrein 9 (KLK9) in liver cancer and to determine its significance.Methods The expression of KLK9 in liver cancer was detected by immunohistochemistry and RT-PCR techniques.Results The rate of expression of KLK9 protein in liver cancer tissues was significantly higher than paracarcinoma tissues and normal liver tissues (P ＜ 0.05).The expression of KLK9 mRNA in liver cancer cells was significantly higher than normal liver cells (P ＜ 0.05).The expression of KLK9 was related to metastasis,size of tumors,degree of malignancy and clinical staging of the liver cancer (P ≤ 0.05),but there was no associated with age,HbsAg and sex (P ＞ 0.05).Conclusions KLK9 may play an important role in the occurrence and development of liver cancer.It may be used as a tumor marker and a prognostic factor.It may also provide a theoretical basis for the diagnosis and biological targeted therapy of liver cancer.
