The incidence of Mycobacterium tuberculosis infection among human immunodeficiency virus-infected individuals in Shanghai and Yunnan Province
10.3760/cma.j.issn.1000-6680.2014.10.003
- VernacularTitle:云南和上海两地人类免疫缺陷病毒感染者合并潜伏性结核分枝杆菌感染情况
- Author:
Xinyun ZHANG
;
Yan GAO
;
Lingyun SHAO
;
Yunya XU
;
Weimin JIANG
;
Wenhong ZHANG
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Mycobacterium tuberculosis;
CD4+ T lymphocyte;
CD8+ T lymphocyte
- From:
Chinese Journal of Infectious Diseases
2014;32(10):585-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the incidence of Mycobacterium tuberculosis (TB) infection among human immunodeficiency virus (HIV)-infected individuals in Shanghai and Yunnan Province and to analyze the risk factors of TB infection.Methods Seventy HIV-infected individuals from Yunnan Province and 67 from Shanghai were enrolled.T-SPOT.TB was employed to detect TB-specific T cells in the peripheral blood mononuclear cells (PBMC).CD4+ and CD8+ T cells in PBMC from the enrolled subjects were detected by flow cytometry.Data were analyzed using Mann-Whitney test,Fisher's exact test and Logistic regression.Results The incidence of latent tuberculosis (LTB) infection among HIV-infected individuals in Yunnan Province was 64.3 ％ (45/70),which was much higher than Shanghai (20.8％ [14/ 67]).The median CD4+ T cell count of HIV-infected individuals with LTB infection in Yunnan Province was 509/μL,while that in Shanghai was 324/μL,which was significant different (U=148,P=0.003).The median CD4+ T cell count in HIV single infected individuals from Yunnan Province was 418/μL,which was not significantly different from that of H IV + LTB individuals from that area (U =378,P =0.120).Moreover,the median CD8+ T cell counts of HIV-infected individuals with latent tuberculosis infection in Yunnan Province and Shanghai were 409/μL and 781/μL,respectively (U=109,P＜0.01).Conclusions The incidence of LTB infection among HIV-infected individuals in Yunnan Province is significantly higher than Shanghai.CD4+ and CD8+ T cell counts are correlated with TB infection among HIV-infected individuals.
