Relationship study of the expressions of Slit2 and Nogo-A in rats with cerebral hemorrhage
10.3760/cma.j.issn.1008-1372.2015.02.011
- VernacularTitle:大鼠脑出血后同侧海马区Slit2、 Nogo-A表达的相关研究
- Author:
Fengbo WANG
;
Qiongfen WANG
;
Hong ZHANG
;
Fei LI
;
Mingwei TANG
- Publication Type:Journal Article
- Keywords:
Cerebral hemorrhage/ME/PA;
Nerve tissue proteins/ME;
Myelin proteins/ME
- From:
Journal of Chinese Physician
2015;17(2):195-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expressions of Slit2 and Nogo-A in the ipsilateral hippocampus after cerebral hemorrhage in rats.Methods A total of 64 adult Sprague-Dawley (SD) rats was randomly divided into control and model groups.Collagenase Ⅶ was used to induce cerebral hemorrhage model.Immunohistochemistry was used to detect the expressions of Slit2 and Nogo-A in hippocampus at the cerebral hemorrhage side at the time points (24 h,7 d,14 d,and 21 d).Results Compared to the control group,the expressions of Slit2 and Nogo-A were significantly enhanced in model group (P ＜0.01),with the highest level at the 7 d.Conclutions Cerebral hemorrhage can significantly enhance expressions of Slit2 and Nogo-A with a positive correlation of Slit2 and Nogo-A,which might have an important effect on the recovery of brain injury.
