Double-Blind Study of Intrarectal Administration of Anesthetic Agent for Pain Control during Transrectal Prostatic Biopsy.
- Author:
Im Chan PARK
1
;
Young Beom JEOUNG
;
Young Kyoung PARK
;
Jong Kwan PARK
Author Information
1. Department of Urology, Medical School, and Institute for Medical Sciences, Chonbuk National University, Chonju, Korea. rain@moak.chonbuk.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Anesthetic agents;
Prostate biopsy;
Lidocaine;
Benzocaine
- MeSH:
Anesthesia;
Anesthetics;
Benzocaine;
Biopsy*;
Double-Blind Method*;
Humans;
Lidocaine;
Male;
Prospective Studies;
Prostate;
Visual Analog Scale
- From:Korean Journal of Andrology
2002;20(3):153-156
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We evaluated the safety and efficacy of intrarectal administration of anesthetic agent for transrectal prostate biopsy. MATERIALS AND METHODS: For a double-blind prospective trial, 100 men undergoing transrectal prostate biopsy were randomized into three groups using an established list. In the control group (n=36), 40mL of normal saline was administered transrectally 10 min before the procedure. The lidocaine group (n=31) and the benzocaine group (n=33) were give 40 mL of 1% lidocaine and 0.3% benzocaine, respectively. Patients were asked to score the severity of the pain expected before and after the biopsy procedure using a self-administered verbal rating scale. Pain was assessed using a 10-point linear visual analog scale. RESULTS: The median pain score expected before the transrectal prostate biopsy was 6.7+/-0.3, 7.1+/-0.2, and 6.7+/-0.3 in the control, lidocaine, and benzocaine group, respectively. The median pain score during the biopsy was 6.1+/-0.3, 5.8+/-0.3 (P<0.05), and 5.9+/-0.4 in the control, lidocaine, and benzocaine group, respectively. Ninety seven percent of the control group, 100% of the lidocaine group, and 91% of the benzocaine group complained of severe and bothersome pain, with a score of 5 or greater during the biopsy. No adverse events were noted. CONCLUSIONS: Intrarectal administration of anesthetic agent is a simple, safe, and efficacious method of providing satisfactory anesthesia in patients undergoing transrectal prostate biopsy. We recommend 1% lidocaine solution in the patients to perform transrectal prostatic biopsy.
