The mechanism of Glutathione in the prevention of ventilator -associated lung injury

VernacularTitle:谷胱甘肽在预防呼吸机相关性肺损伤中的作用机制分析
Author: Linggui KONG ; Hui WEN ; Baoqing DU ; Shuling SONG ; Meng ZHAO
Publication Type:Journal Article
Keywords: Glutathione; Ventilator-associated lung injury; Mechanical ventilation
From: Chinese Journal of Primary Medicine and Pharmacy 2015;(8):1125-1126
CountryChina
Language:Chinese
Abstract: Objective To investigate the mechanism of Glutathione in the prevention of ventilator-associated lung injury.Methods 30 mechanical ventilation patients who were healthy before were selected and randomly divided into the two groups.Group A was the high tidal volume group:10mL/kg;group B was used the tidal volume plus the injection of Glutathione(2.4g/d).After 48 hours,we collected lavage fluid and use Coomassie brilliant blue to detect the protein content of alveolar lavage fluid of the two groups.Results There was a significant difference (P<0.01)between the two groups.The protein content in group A[(9.90 ±2.25)g/L]was higher than that of group B [(4.17 ±0.39)g/L],and there was statistically significant (P<0.01).Conclusion Glutathione can reduce the incidence of ventilator-associated lung injury and prevent the occurrence of ventilator-associated lung injury.