Martin's Equation as the Most Suitable Method for Estimation of Low-Density Lipoprotein Cholesterol Levels in Korean Adults.
10.4082/kjfm.2017.38.5.263
- Author:
Mijeong KANG
1
;
Jongwoo KIM
;
Seon Yeong LEE
;
Kyunam KIM
;
Junehyung YOON
;
Hongseok KI
Author Information
1. Department of Family Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea. s2700@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Dyslipidemias;
Low-Density Lipoprotein Cholesterol;
Friedewald Equation;
Martin Equation
- MeSH:
Adult*;
Cholesterol*;
Dyslipidemias;
Humans;
Lipoproteins*;
Methods*;
Seoul;
Triglycerides
- From:Korean Journal of Family Medicine
2017;38(5):263-269
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Friedewald equation is the most widely used method for estimating low-density lipoprotein cholesterol (LDL-C) level. However, due to potential over- or underestimation, many studies have used a modified equation. This study aimed to compare estimates by 4 different equations to directly measured LDL-C concentrations in order to propose the most appropriate method for LDL-C estimation in the Korean population. METHODS: We studied data of 4,350 subjects that included total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and LDL-C concentrations that had been measured at one university hospital in Seoul. We investigated 4 equations: LDL-C by Friedewald's original equation (LDL-C(F)) and its 3 modifications. Pearson correlation analysis was performed to compare these estimates to the direct measurement. RESULTS: Pearson correlation analysis revealed a good correlation among all 4 estimated LDL-C values and the directly measured LDL-C value. The Pearson coefficients were 0.951 for LDL-C(F), 0.917 for LDL-C by Hatta equation (LDL-C(H)), 0.968 for LDL-C by Puavilai equation (LDL-C(P)), and 0.983 for LDL-C by Martin equation (LDL-C(M)). Martin equation (LDL-C(M)) resulted in the best approximation (mean difference from the direct measurement, 5.5 mg/dL; mean percentage difference from the direct measurement, 5.1%) and the best agreement with the direct measurement (86.1%). LDL-C(P) resulted in the second-best approximation (mean difference, 7.0 mg/dL; mean percentage difference, 6.2%; concordance, 82.5%). LDL-C(M) was found to be less influenced by TG and HDL-C levels than by LDL-C(F). CONCLUSION: Estimates by Martin equation had the best agreement with direct LDL-C concentrations and both Martin and Puavilai equations were superior to Friedewald equation for estimating LDL-C concentrations in Korean adults.
