The effect of fluvastatin sodium on MMP-9 expression in tongue squamous carcinoma Tca81 1 3 cells
10.3969/j.issn.1001-3733.2015.02.026
- VernacularTitle:氟伐他汀钠对舌鳞癌Tca8113细胞基质金属蛋白酶-9表达影响的研究
- Author:
Guangwei QIAO
;
Haiping TANG
;
Jie JING
- Publication Type:Journal Article
- Keywords:
Fluvastatin Sodium(FS);
Tongue squamous cell carcinoma;
Matrix metailoproteinase-9 (MMP-9)
- From:
Journal of Practical Stomatology
2015;(2):262-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of fluvastatin sodium (FS ) on MMP-9 expression in tongue squamous carcinoma Tca81 1 3 cells.Methods:Immunofluorescence method and Western blot were used to detect the level of MMP-9 expression in Tca81 1 3 cells treated by different concentration of FS for 24 h,the data were statistically analyzed.Results:MMP-9 expression in FS treated cells was significantly reduced(P<0.05)compared with control cells.With FS concentration increase the protein expression decreased in a dose-dependant manner detected by the 2 mothods.Conclusion:Fluvastatin Sodium can dose-dependantly inhibit the expression level of MMP-9 in Tca81 1 3 cells.
