Changes of Th17 and its related factors in hepatocellular carcinoma with hepatitis B virus infection
10.3969/j.issn.1000-484X.2015.04.019
- VernacularTitle:IL－2、IL－4、IL－6、IFN－γ、IL－17 A在肝癌组织中表达及其与乙肝病毒感染的关系
- Author:
Chuanzhong HUANG
;
Jieyu LI
;
Shuping CHEN
;
Fang LIU
;
Yunbin YE
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Th17;
Hepatitis B virus;
Cytometric bead array
- From:
Chinese Journal of Immunology
2015;(4):527-530
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the significance of Th17 in hepatocellular carcinoma, expecially with HBV infection.Methods:Cytometric bead array(CBA) was employed to detect 5 cytokines(IL-2,IL-4,IL-6,IFN-γ,IL-17A)from 39 tumor and non-tumor tissues of HCC and combined clinical data for comparative statistic analysis.Results:The expression of IL-2,IL-4,IFN-γin liver cancer tissue[(4.61±0.28),(3.37±0.58),(3.08±1.08)pg/ml,respectively] was significant lower than non-cancer tissue [(5.57±0.59),(3.77±0.70),(3.69±1.20)pg/ml,respectively].Otherwise,the expression of IL-6,IL-17A in cancer tissue [(280.09±254.68), (2.66±1.66) pg/ml, respectively] was higher than non-cancer [(6.58 ±1.92), (1.49 ±0.98) pg/ml, respectively].And,whatever cancer or non-cancer tissue,the expression of IL-17A in tissue[(3.45±1.86)pg/ml] with high HBV load (>1 000 U/ml) was significant higher than tissue with low HBV load[(1.97±1.16)pg/ml].Conclusion: IL-17A was highly expressed in HCC,and IL-2,IL-4,IFN-γmay inhibit its expression,and IL-6 may promote it.Hepatitis B virus infection may promote Th17 expression,thereby reducing patient′s prognosis.
