Probabilities of Pulmonary and Cardiac Complications and Radiographic Parameters in Breast Cancer Radiotherapy.
10.3857/jkstro.2010.28.1.23
- Author:
O Kyu NOH
1
;
Sung Ho PARK
;
Seung Do AHN
;
Eun Kyung CHOI
;
Sang Wook LEE
;
Si Yeol SONG
;
Sang Min YOON
;
Jong Hoon KIM
Author Information
1. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sdahn@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
NTCP;
Breast cancer radiotherapy;
Radiographic parameter;
Radiation pneumonitis;
Cardiac toxicity
- MeSH:
Breast;
Breast Neoplasms;
Heart;
Hockey;
Humans;
Lung;
Pneumonia;
Radiation Pneumonitis;
Thoracic Wall
- From:The Journal of the Korean Society for Therapeutic Radiology and Oncology
2010;28(1):23-31
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the relationship between the normal tissue complication probability (NTCP) of 3- dimensional (3-D) radiotherapy and the radiographic parameters of 2-dimensional (2-D) radiotherapy such as central lung distance (CLD) and maximal heart distance (MHD). MATERIALS AND METHODS: We analyzed 110 patients who were treated with postoperative radiotherapy for breast cancer. A two-field tangential technique, a three-field technique, and the reverse hockey stick method were used. The radiation dose administered to whole breast or the chest wall was 50.4 Gy, whereas a 45 Gy was administered to the supraclavicular field. The NTCPs of the heart and lung were calculated by the modified Lyman model and the relative seriality model. RESULTS: For all patients, the NTCPs of radiation-induced pneumonitis and cardiac mortality were 0.5% and 0.7%, respectively. The NTCP of radiation-induced pneumonitis was higher in patients treated with the reverse hockey stick method than in those treated by other two techniques (0.0%, 0.0%, 3.1%, p<0.001). The NTCP of radiation-induced pneumonitis increased with CLD. The NTCP of cardiac mortality increased with MHD (R2=0.808). CONCLUSION: We found a close correlation between the NTCP of 3-D radiotherapy and 2-D radiographic parameters. Our results are useful to reanalyze the previous 2-D based clinical reports about breast radiation therapy complications as a viewpoint of NTCP.
