Expression and clinical value of serum thymidine kinase 1 in patients with acute exacerbation of chronic obstructive pulmonary disease

VernacularTitle:血清胸苷激酶1在慢性阻塞性肺疾病急性加重期患者中的临床价值
Author: Yin LIU ; Mengmeng JIN ; Zhendong QIAN ; Meili CHEN ; Rui HUANG ; Ting DU ; Yanbei ZHANG
Publication Type:Journal Article
Keywords: Acute exacerbation of chronic obstructive pulmonary disease; Serum thymidine kinase 1; Efficacy
From: The Journal of Practical Medicine 2015;(9):1431-1433
CountryChina
Language:Chinese
Abstract: Objective To investigate the relations and evaluation value of serum thymidine kinase 1 (sTK1) in the treatment of patients withacute exacerbation of chronic obstructive pulmonarydisease (AECOPD). Methods The retrospective treating studies were performed on 104 patients with AECOPD , sTK1 level was de-tected by chemiluminescence dot-blot assay before and after treatment , and the correlation between the expression of sTK1 and CRP after treatment in the two groups was analyzed. Results The levels of sTK1 and CRP in the ef-fective group significantly lowered after treatment (P < 0.05). The expression of sTK1 in the effective group and in the ineffective group after treatment was significantlycorrelated with CRP (P < 0.05). Conclusion sTK1 can be used as a valuable indicator to evaluate the severity of AECOPD and to estimate the efficacy of AECOPD thera-py.