Relationships between HBV-M patterns and liver function,HBV-DNA in patients with chronic HBV infection of different stages
10.3969/j.issn.1673-4130.2015.04.001
- VernacularTitle:不同病期慢性HBV感染者肝功能、HBV-DNA与HBV-M模式的关系
- Author:
Yali ZENG
;
Qingfeng MA
;
Wei XIONG
;
Liang XIONG
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
hepatitis;
liver cirrhosis;
hepatocellular carcinoma
- From:
International Journal of Laboratory Medicine
2015;(4):433-435
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of five indicators of hepatitis B(HBV-M)and its relationship with liver function parameters and HBV-DNA load in patients with chronic HBV infection in different stages.Methods The serum samples were collected from 456 patients infected with HBV.The HBV-M,liver functional parameters and HBV-DNA level were quantita-tively detected.According to the stages of disease,the patients were divided into 3 groups including chronic hepatitis B group(inclu-ding mild subgroup,moderate subgroup and severe subgroup),liver cirrhosis group(including compensatory subgroup,decompen-sated subgroup)and hepatocellular carcinoma goup.Results The ratio of HBsAg,HBeAg,HBcAb positive pattern(135 pattern) and HBsAg,HBeAb,HBcAb positive pattern(145 pattern)in the three groups were statistically different(P <0.05).In each chron-ic hepatitis B subgroup,both ALT and AST levels of 135 pattern were significantly higher than the other two patterns(P <0.05). In each liver cirrhosis subgroup and hepatocellular carcinoma group,there were statistically significant differences in ALB and TBIL levels between the three patterns(P <0.05 ).In each group,the HBV-DNA level of 135 positive pattern were significantly higher than the other two patterns(P <0.05).Conclusion With the advancement of chronic hepatitis B,there is a downtrend in the ratio of 135 pattern and increasing trend in the ratio of 145 pattern.If the stage of hepatitis B is discriminated,ALT,AST,ALB TBIL and HBV-DNA level were closely related to HBV-M pattern.
