Clinicopathological study on 18 cases of primary cervical small cell carcinoma
10.13315/j.cnki.cjcep.2015.01.004
- VernacularTitle:原发性子宫颈小细胞癌18例临床病理观察
- Author:
Wei ZHANG
;
Bo YU
;
Jianjun WANG
;
Yan HE
;
Hai WANG
;
Jiandong WANG
;
Xiaojun ZHOU
;
Qunli SHI
- Publication Type:Journal Article
- Keywords:
cervix neoplasm;
small cell carcinoma;
HPV;
immunohistochemistry;
in situ hybridization;
ultrastructure
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(1):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the clinicopathological and immunohistochemical features of primary small cell carcinoma of the cervix ( SCCC) and its prognosis. Methods 18 cases of primary cervical small cell carcinoma were evaluated by histopathology, in si-tu hybridization and immunohistochemistry and relevant literatures were reviewed. Results The age of the patients ranged from 30 to 69 years ( mean age, 40 years) . Major clinical manifestation was irregular colporrhagia. Colposcopy often revealed a cervical mass or cervical erosion. Microscopically, the tumor cells were small and round and arranged in a solid distribution. The cell had little cyto-plasm and increased karyoplasmic ratio with deeply stained granular chromatin and increased pathological mitosis. Immunohistochemi-cally, the tumor cells were often positive for CKpan, variable positive for Syn, NES, CgA, CD56 and p16. HPV 16/18 were positive in 4 cases. Conclusion SCCC is a neuroendocrine tumor of high malignancy and poor prognosis with a possible pathogenesis of HPV 16/18 infection. CKpan, Syn, CgA, NSE and CD56 are useful markers for the diagnosis of SCCC.
