Internal mammary sentinel lymph node biopsy in breast cancer pa-tients with clinically positive axillary lymph nodes
10.3969/j.issn.1000-8179.20150009
- VernacularTitle:临床腋窝淋巴结阳性乳腺癌患者内乳区前哨淋巴结活检术研究
- Author:
Xiao SUN
;
Binbin CONG
;
Pengfei QIU
;
Zhaopeng ZHANG
;
Zhengbo ZHOU
;
Yanbing LIU
;
Peng CHEN
;
Tong ZHAO
;
Chunjian WANG
;
Yongsheng WANG
- Publication Type:Journal Article
- Keywords:
breast cancer;
sentinel lymph node biopsy;
internal mammary node
- From:
Chinese Journal of Clinical Oncology
2015;(6):341-344
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study was conducted to evaluate the roles of internal mammary sentinel lymph node biopsy (IM-SL-NB) in the treatment of breast cancer patients with clinically positive axillary lymph nodes. Methods:This study is a one-armed clini-cal research conducted from June 2013 to October 2014. A total of 64 breast cancer patients from Shandong Cancer Hospital with clini-cally positive axillary lymph nodes were enrolled in the study. All patients underwent axillary lymph node dissection. Meanwhile, IM-SLNB was performed in all patients using the new injection method of radiotracer. Results:Among the 64 enrolled patients, the visual-ization rate of internal mammary lymph node was 59.4%(38/64). For the 38 patients who were subjected to visualization of the internal mammary node, the detection rate was 100%(38/38), and the incidence of complications was 7.9%(3/38). The metastasis rate of inter-nal mammary lymph node was 21.1%(8/38). Patients with upper inner quadrant tumors and metastasis of more axillary lymph nodes had a significantly higher chance of developing sentinel lymph node metastasis (P<0.001 and P=0.017, respectively) than the other pa-tients. The clinical benefit rate of the above mentioned treatment was 59.4%. Among the patients, 12.5%(8/64) received extra internal mammary radiotherapy, whereas 46.9%(30/64) patients avoided the unnecessary internal mammary radiotherapy. Conclusion:IM-SL-NB should be performed in breast cancer patients with clinically positive axillary lymph nodes because IM-SLNB could provide the ac-curate indication of radiation to the internal mammary area, especially for the patients with upper inner quadrant tumors and those with a suspiciously high level of axillary lymph node metastasis.
