Lipoic acid protects dopaminergic neurons in LPS-induced model of Parkinson’s disease
10.3969/j.issn.1000-4718.2015.02.002
- VernacularTitle:硫辛酸对 LPS 诱导的帕金森病小鼠黑质多巴胺能神经元损伤的影响
- Author:
Yanhua LI
;
Qing HE
;
Jiezhong YU
;
Chunyun LIU
;
Jianjun HUANG
;
Ling FENG
;
Zhi CHAI
;
Qing WANG
;
Baoguo XIAO
;
Cungen MA
- Publication Type:Journal Article
- Keywords:
Lipopolysaccharide;
Parkinson disease;
Lipoic acid;
Microglia
- From:
Chinese Journal of Pathophysiology
2015;(2):201-206
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the effect of lipoic acid ( LA) on LPS-induced Parkinson disease ( PD) model of mice.METHODS:Female C57BL/6 mice of 10-month-old were randomly divided into saline control group , PD group and LA group.The PD mouse model was induced by intranasal instillation of LPS .Assays of tyrosine hydroxylase , microglia and nuclear factor kappa B ( NF-κB) were performed by the methods of immunohistochemistry and Western blotting .RE-SULTS:Intranasal LPS instillation exhibited basic characteristics of PD model .However, LA administration significantly improved motor dysfunction , protected dopaminergic neurons from damage , and inhibited NF-κB activation in inflammatory microglia in the substantia nigra area of the brain .CONCLUSION:LA may exert a profound neuroprotective effect by an-ti-neuroinflammatory reaction to arrest the progression of PD .
