Evaluation of TNM staging system and pT2 subdivisions of pathological substaging in patients with clinically localized prostate cancer undergoing radical prostatectomy
10.13315/j.cnki.cjcep.2015.02.015
- VernacularTitle:根治性前列腺癌病理分期及pT2病理亚分期的意义
- Author:
Yunfan WANG
;
Miaozi GONG
;
Qi MIAO
;
Jinxia ZHANG
- Publication Type:Journal Article
- Keywords:
prostate neoplasms;
prostatectomy;
tumor stage;
pathologic staging
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(2):178-180
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To evaluate the subclassifications of pT2 diseases in tumor-nodes-metastases ( TNM) staging system for prostate cancer. Methods A retrospective analysis of the medical records of patients who underwent radical prostatectomy ( RP) with the diag-nosis of clinically localized PCa was conducted. Any preoperative therapies, in terms of active surveillance, hormone therapy or radia-tion were exclusion criteria. The RP specimens were completely embedded and histopathologically evaluated for extraprostatic exten-sion, seminal vesicle invasion and staged according to the 2002/2010 TNM staging criteria. Results Using current 2002/2010 TNM staging criteria, in all, 15 cases of the tumors were pT2, 10 cases were pT3a, and 5 cases were pT3a. When subclassification of pT2, 2 cases of the tumors were pT2a, 13 cases of the tumors were pT2c, and none was identified as a pathological T2b tumor. Conclusion The results of the present study suggest that the pathological substaging criteria of organ-confined prostate cancer via methods used in the current 2002/2010 TNM staging system may not be appropriate. Efforts should be made to upgrade the current TNM staging system for prostate cancer.
