Expression of Apaf-1 and Caspase-9 in prostate cancer and its clinical significance
10.13315/j.cnki.cjcep.2015.02.008
- VernacularTitle:前列腺癌组织中Apaf-1和Caspase-9表达及临床意义
- Author:
Bingxin ZHANG
;
Xia ZHAO
;
Xihua JIA
;
Yang LIU
;
Jinku ZHANG
- Publication Type:Journal Article
- Keywords:
prostatic neoplsms;
benign prostatic hyperplasia;
Apaf-1;
Caspase-9
- From:
Chinese Journal of Clinical and Experimental Pathology
2015;(2):151-153
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the expression of Apaf-1 and Caspase-9 in prostate cancer ( PCa) and benign prostatic hyperplasia ( BPH) , and to analyze their correlation with clinicopathological parameters of PCa. Methods Immunohistochemistry was used to de-tect Apaf-1 and Caspase-9 protein in 45 cases of PCa and 60 cases of BPH. Results The positive rate of Apaf-1 and Caspase-9 in PCa tissues was significantly lower than that in BPH (P<0. 05). The expression of Apaf-1 and Caspase-9 was not correlated with the age of patients and distant metastasis (P>0. 05), but it was correlated with the pathological grade and clinical stage of PCa (P<0. 05). Conclusion Apaf-1 and Caspase-9 are lowly expressed in PCa. There is positive correlation between the expression of Apaf-1 and Caspase-9 (rs =0. 645, P<0. 01). Apaf-1 and Caspase-9 might be correlated with the carcinogenesis and development of PCa.
