Determination of Phenol and L-Menthol in Glycerin Zhiyang Lotions by GC
- VernacularTitle:GC法测定甘油止痒洗剂中苯酚和薄荷脑的含量
- Author:
Liping CHENG
;
Yu HUAN
;
Hongyu ZHAO
;
Xu CHU
;
Xujing ZHUO
;
Zhenting YUAN
- Publication Type:Journal Article
- Keywords:
GC;
Phenol;
L-menthol;
Zhiyang lotions;
Glycerin
- From:
China Pharmacist
2014;(11):1815-1817
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish a GC method for the determination of phenol and L-menthol in glycerin Zhiyang lotions. Meth-ods:A Zebron ZB-WAX(0. 32 mm × 30. 0 m,0. 50 μm) capillary column was used with an FID detector. The column temperature was 60℃, maintained for 1 min, and then raised to 160℃ at the rate of 8℃·min-1 , and maintained 10 minutes. The inlet tempera-ture was 180℃, the detector temperature was 300℃, and the carrier gas was nitrogen. Results:The linear range of phenol and L-men-thol was 0. 5-10. 0 mg·ml-1(r=0. 999 9) and 0. 25-5. 0 mg·ml-1(r=0. 999 9), respectively. The average recovery of phenol and L-menthol was 99. 01%(RSD=0. 90%,n=9)and 99. 70%(RSD=0. 98%,n=9), respectively. Conclusion: The method is sim-ple, accurate and reliable, and can be used to determine the concentration of phenol and L-menthol in glycerin Zhiyang lotions.
