Correlation between expression of Ki-67, PCNA and sensitivity of adjuvant chemotherapy in breast cancer patients
10.3969/j.issn.1000-484X.2014.11.026
- VernacularTitle:Ki-67和PCNA表达与乳腺癌及乳腺癌化疗敏感性的关系
- Author:
Xin WEI
;
Julun YANG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Ki-67;
PCNA;
Sensitivity of chemotherapy
- From:
Chinese Journal of Immunology
2014;(11):1549-1551
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the nuclear proliferation in breast cancer tissue related antigen (Ki-67) and proliferating cell nucleus antigen ( PCNA ) expression changes and the relationship between breast cancer and its relationship to breast cancer chemotherapy sensitivity, provide theoretical basis for clinical effective chemotherapy of breast cancer.Methods: Subjects from our hospital in recent years,by clinical examination,84 cases of patients diagnosed with breast cancer,breast cancer tissue were measured with immunohistochemical method of Ki-67 and PCNA content, compared different Ki-67 and PCNA expression levels of patients undergoing chemotherapy curative effect difference.Results:Ki-67 positive cases for 52 cases,PCNA positive cases of 62 cases.Ki-67 positive rate and the patients with lymph node metastasis and tumor classification stage were positively correlated,the difference was sta-tistically significant,P<0.05).The PCNA positive rate and the tumor was closely relative to lymph node metastasis,P<0.05,has nothing to do with tumor clinical classification stage(P>0.05).The total effective rate of Ki-67+was significantly higher than that of Ki-67-(80.8%and 56.2%,P<0.05).Effective rate of PCNA-significantly higher than that of PCNA+(72.7% to 45.2%,P<0.05).Conclusion:Ki-67 clinical data and PCNA expression is closely related to breast cancer and chemotherapy sensitivity.It can be used as a prediction index of curative effect of chemotherapy.
