Abnormal vascular endothelial cell junctions caused by PDK1 deficiency
10.3969/j.issn.1006-5725.2014.17.004
- VernacularTitle:PDK1缺失导致血管内皮细胞连接异常
- Author:
Qiuting FENG
;
Xiaojun QIAN
;
Xin XU
;
Yan JIN
;
Chengjian YANG
- Publication Type:Journal Article
- Keywords:
PDK1;
Vascular endothelial cells;
Cell connection;
Knockout
- From:
The Journal of Practical Medicine
2014;(17):2706-2708
- CountryChina
- Language:Chinese
-
Abstract:
Objective To reveal the role of PDK1 in vascular endothelial cells. Methods PDK1 was knocked out in endothelial cells by recombinase-mediated Cre to observe it′s effects on vascular endothelial cells. Results Abnormality of vascular development in rats could be found as a result of endothelial PDK1 deletion. Meanwhile, vascular leakage and bleeding phenotype were observed, and tissue analysis showed vascular endothelial cells abnormalities. Conclusions PDK1 plays an important role in the functioning and integrity of vascular endothelial cells, which made tentative explanation for PDK1-Akt signal path and laid basis for further research.
