The diagnostic value of cytokeratin 19 fragment in non small-cell lung cancer

VernacularTitle:血清细胞角蛋白19片段对非小细胞肺癌的诊断价值
Author: Changzheng LIAO ; Yi LUO ; Wenli XU ; Shengxiao WEI ; Lei ZHU ; Ruihuan XU
Publication Type:Journal Article
Keywords: cytokeratin 19 fragment; reference interval; non-small cell lung cancer; receiver operating characteristic curve
From: International Journal of Laboratory Medicine 2014;(19):2616-2617
CountryChina
Language:Chinese
Abstract: Objective To discuss the diagnostic value of cytokeratin 19 fragment(CYFRA21-1) in non small-cell lung cancer (NSCLC) .Methods The serum CYFRA21-1 levels were tested in 1 046 healthy adults(healthy group) ,244 benign pulmonary dis-ease patients(benign disease group) and 90 NSCLC patients(NSCLC group) .The results were analyzed statistically .Results There was not significantly difference between man and women in healthy group for CYFRA21-1 level(P>0 .05) .The CYFRA21-1 level in more than 60 years cases was obviously higher than that in less than 18-40 years group and >40-60 group .The upper limit of serum CYFRA21-1 was 4 .00 ng/mL according 95% confidence interval of benign disease group .A cut-off value of 4 .70 ng/mL in NSCLC group was suggested when compared with receiver operating characteristic curve(ROC curve) ,and its sensitivity and speci-ficity were 62 .1% and 92 .6% respectively .Conclusion The diagnostic value for serum CYFRA21-1 in NSCLC was 4 .70 ng/mL .