The research advance of the relationship between vitamin D binding protein and cancer
10.3760/cma.j.issn.1009-9158.2014.11.008
- VernacularTitle:维生素D结合蛋白与肿瘤的关系研究进展
- Author:
Qiulian ZHONG
;
Huayi HUANG
- Publication Type:Journal Article
- Keywords:
Vitamin D-binding protein;
Vitamin D;
Macrophage-activating factors;
Neoplasms
- From:
Chinese Journal of Laboratory Medicine
2014;(11):828-831
- CountryChina
- Language:Chinese
-
Abstract:
Vitamin D binding protein ( VDBP) is a multi-functional plasma globulin which binds to the vitamin D ( VD) in the circulation system and transporting the latter to various effective organs to exert its biological functions .Studies have found that VD and its carrier VDBP are associated with the risk of various cancers such as breast cancer , prostate cancer , and colorectal cancer however , lacking sufficient epidemiological evidences so far .Furthermore , it is still controversial regarding how VD controls and affects cancer progression.In addition, studies have also demonstrated that VDBP derived macrophage-activating factor (GcMAF) is a potent lymphokine in cancer treatment .Nonetheless, the relationship between VDBP and cancer including the VDBP polymorphism, VDBP plasma concentration are still unclear; more studies are needed to further uncover its role in cancer development and progression , thus providing new evidences for cancer diagnosis, treatment, and prognosis.
