Effect of Cytochrome P-450 4F2 Gene Polymorphisms in Patients With Warfarin for Initial Doses in 7 Days
10.3969/j.issn.1000-3614.2014.11.014
- VernacularTitle:细胞色素P450酶4F2基因多态性对中国人服用华法林起始七天内剂量的影响
- Author:
Xiaowei XIONG
;
Hong LIU
;
Lulu HAN
;
Ying LOU
;
Lu HUA
;
Yan LI
;
Yishi LI
- Publication Type:Journal Article
- Keywords:
Warfarin;
Cytochrome P-450 4F2 gene polymorphisms;
Initial dose
- From:
Chinese Circulation Journal
2014;(11):910-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effect of cytochrome P-450 4F2 (CYP4F2, rs2108622) gene polymorphisms in patients with warfarin for initial doses in 7 days.
Methods: A total of 271 patients treated by warfarin were studied. The CYP4F2 gene polymorphisms were assessed by real-time PCR, the average initial warfarin doses in 7 days and the time of international normalized ratio (INR) ifrst arrived to therapeutic range were recorded. The differences of initial warfarin doses and the time of INR ifrst arrived to therapeutic range among CYP4F2 gene polymorphisms of CC, CT and TT genotypes were analyzed by statistical method.
Results: The average initial warfarin doses among CYP4F2 polymorphisms of TT and CT/TT were higher than CC, P<0.05. The times of INR first arrived to therapeutic range in TT genotype was higher than CC genotype, P<0.05. With adjusted gender, age, body height and weight, CYP2C9 and VKORC1 polymorphisms, conditions of disease and medication, the effect of CYP4F2 gene polymorphisms on initial warfarin doses in 7 days were still with the statistic meaning (regression coefifcient=0.21, P=0.003).
Conclusion: CYP4F2 polymorphisms inlfuenced the initial warfarin doses in 7 days in relevant patients.
