Study of the distribution of HPV infective genotypes in healthy women and cervical carcinoma patients
10.3969/j.issn.1673-4130.2014.22.007
- VernacularTitle:健康妇女及宫颈癌患者HPV感染基因型分布的研究
- Author:
Yanting XU
;
Weimin CAI
;
Jianxiang GENG
;
Xuemei FAN
;
Xiaolan XU
;
Hongjing WANG
;
Xiurong LONG
;
Jin TAN
;
Xue ZHAO
- Publication Type:Journal Article
- Keywords:
cervix uteri;
human papilloma virus;
genotypes;
gene-chip technology
- From:
International Journal of Laboratory Medicine
2014;(22):3022-3024
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the genotype distribution of HPV in cervical cells of natural crowd and tissues of cervical in‐traepithelial neoplasia(CINⅢ grade) and cervical carcinomas patients .Methods PCR and gene‐chip technology were utilized for the genotype detection of 23 kinds of HPV in cell specimens from 1 047 women of natural crowd (normal group) and tissue specimens from 173 cases of cervical intraepithelial neoplasia(precancerosis group) and 133 cases of patients with cervical carcinoma (cervical carcinoma group) .Results There were 109 ,159 and 121 cases of HPV positive specimens respectively in normal group ,precancer‐osis group and cervical carcinoma group ,and the HPV infection rates were 10 .41% (109/1 047) ,91 .91% (159/173) and 90 .98%(121/133) ,respectively .Conclusion PCR and gene‐chip technology can be used to detect HPV genotypes in cervical cells and cer‐vical tissues specimens .
