Advances in Study on MicroRNAs and their Target Genes in Occurrence,Development and Treatment of Gastric Cancer
10.3969/j.issn.1008-7125.2014.12.010
- VernacularTitle:胃癌发生、发展和治疗相关microRNAs及其作用靶点的研究进展
- Author:
Mengzhou GUO
;
Yuehong CUI
;
Tianshu LIU
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
MicroRNAs;
Target Genes;
Oncogenes;
Genes,Tumor Suppressor
- From:
Chinese Journal of Gastroenterology
2014;(12):742-745
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs( miRNAs)are a family of endogenous noncoding small RNA molecules that are approximately 20 nucleotides in length. Aberrant expression or dysfunction of miRNAs and subsequent dysregulation of their target genes might be involved in the occurrence and development of various cancers. Gastric cancer is a leading malignant disease worldwide. Recent studies have shown that some miRNAs are closely associated with the proliferation,migration,invasion, apoptosis and chemosensitivity of gastric cancer cells by regulating their target genes. Advances in study on gastric cancer-related miRNAs,their target genes,and the use of miRNAs-targeted therapy in gastric cancer were reviewed in this article.
