Effects of hemodialysis on immune function of patients with end-stage nephropathy associated HBV virus infection
10.3969/j.issn.1000-484X.2014.12.021
- VernacularTitle:血液透析对终末期肾病合并HBV病毒感染患者免疫功能的影响
- Author:
Qiuyu LEI
;
Jinghong ZHAO
;
Jianying TANG
- Publication Type:Journal Article
- Keywords:
Hemodialysis;
End-stage renal disease;
HBV;
Immune function
- From:
Chinese Journal of Immunology
2014;(12):1679-1682
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of hemodialysis f on immune function of patients with end-stage nephropathy associated HBV virus infection.Methods:50 cases of patients with end-stage nephropathy associated HBV virus infection from June 2011 to June 2013 were randomly selected as observation group.50 cases of patients with end-stage renal disease as the control group.Patients in control group and observation group were treated with continuous hemodialysis therapy .24 h urinary protein ,serum al-bumin,blood urea nitrogen and creatinine in control group and observation group before and after treatment were analyzed .The regulatory T lymphocyte ,the CD8+T lymphocytes,perforin and granzyme B in peripheral blood in control group and observation group before and after treatment were analyzed by flow cytometry.Results:After dialysis treatment ,clinical symptoms and laboratory indexes of the two groups were significantly improved ( P<0.05 ).Clinical symptoms and laboratory indexes in control group and observation group after treatment had no statistical difference ( P>0.05 ).There was no significant change of immune function in the control group before and after treatment ( P>0.05 ).But the ratio of Treg cells and CD 8+T lymphocyte in observation group after treatment were sig-nificantly increased than that of before treatment ( P<0.05 ).Before treatment ,the active molecule perforin and granzyme B expression rate of T cells in the peripheral blood of observation group were higher than the control group ( P<0.05 ).After treatment ,Treg cell and CD8+T lymphocyte ratio were significantly decreased as well as perforin and granzyme B expression rate ( P<0.05 ).Conclusion:Compared with control group ,hemodialysis can significantly improve the immune function of the patients with end -stage nephropathy as-sociated HBV virus infection.
