Advances of molecular targeted therapy based on Wnt signaling pathway in osteoporosis
10.3760/cma.j.issn.1000-6699.2014.08.019
- VernacularTitle:基于Wnt信号通路的骨质疏松症分子靶向治疗研究进展
- Author:
Linghui LI
;
Hongsheng ZHAN
;
Daofang DING
;
Bo CHEN
;
Guoqing DU
;
Yi SONG
- Publication Type:Journal Article
- Keywords:
Wnt signaling;
Osteoporosis;
Osteoblast
- From:
Chinese Journal of Endocrinology and Metabolism
2014;(8):712-715
- CountryChina
- Language:Chinese
-
Abstract:
The Wnt signaling pathway plays an important role in bone metabolism. Inducing the Wnt signaling pathway promotes bone formation while restraining it results in osteopenic states. Although the regulation of this signaling pathway may bring enormous therapeutic potential, it still requires cautious approach because of the risks of tumorigenesis. The role of the Wnt signaling pathway in bone metabolism and the molecular targets of therapeutic potential for osteoporosis are discussed in this review.
