Diagnostic value of single and combined measurement of serum hs-CRP,Cys-C, andβ2-MG in diabetic nephropathy of early stage

VernacularTitle:超敏C反应蛋白β2微球蛋白胱抑素C联合检测对早期糖尿病肾病的诊断价值
Author: Bing LIU ; Lianyun YANG ; Fei LIU ; Huang LIANG ; Zhicheng HUANG
Publication Type:Journal Article
Keywords: diabetic nephropathy; hypersensitive C-reactive protein; β2-microglobulin; cystatin C
From: International Journal of Laboratory Medicine 2014;(17):2315-2316
CountryChina
Language:Chinese
Abstract: Objective To evaluate the diagostic value of hypersensitive C-reactive protein(hs-CRP),β2-microglobulin(β2-MG) and cystatin C(Cys-C)tests in diabetic nephropathy(DN)of early stage.Methods The turbidimetric immunoassay was adopted to determine serum hs-CRP,β2-MG and Cys-C concentrations in type 2 diabetic patients,including 100 cases with DN of early stage (DN group),50 cases without DN(NDN group)and 100 cases healthy controls(control group).Results Serum hs-CRP,β2-MG and Cys-C concentrations in DN group were significantly higher than that in control group and NDN group(P <0.05).Conclusion Hs-CRP,β2-MG and Cys C are sensitive indicators in the diagosis of DN.The combined determination of the three indicators im-proves the sensitivity of early DN diagnosis and is useful for monitoring the development of DN in early stage.