Clinical outcomes and safety of percutaneous coronary intervention only in single-opened vessel lesion among patients with severe left ventricular systolic dysfunction
10.3969/j.issn.1004-8812.2014.08.006
- VernacularTitle:对冠心病引起的严重心力衰竭三支血管病变仅单支开放的患者行经皮冠状动脉介入治疗的安全性和有效性
- Author:
Dongju JIANG
;
Rong FU
;
Gaopin HU
;
Yulin JIA
;
Dongdong WANG
;
Yanbo ZHANG
;
Bowen XUE
;
Aiping TAO
- Publication Type:Journal Article
- Keywords:
Coronary diseases;
Heart failure;
Single-opened vessel lesion;
Percutaneous coronary intervention
- From:
Chinese Journal of Interventional Cardiology
2014;(8):501-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was conducted to investigate the clinical outcomes and safety of percutaneous coronary intervention (PCI) to the single-opened vessel lesion among patients with severe left ventricular systolic dysfunction. Methods Twenty-seven patients with severe left ventricular systolic dysfunction (ejection fraction≤35%) undergoing PCI were included. All the patients received PCI only to the single-opened vessel lesion under the conditions of: (1) There were limitations to open chronic total occlusion (CTO);(2) Single-opened vessel lesion was not calcified and tortuous. Clinical outcomes, including success rate of PCI, changes of symptoms in-hospital, brain natriuretic peptide (BNP) and left ventricular ejection fraction (LVEF) pre-and one week post-PCI, the major adverse cardiac events (MACE, including death, myocardial infarction and target vessel revascularization) at 30-days after discharged were observed. Results The success rate of PCI was obtained in all 27 patients(100%), and all the patients received drug eluting stent implantation. The symptoms improvement occurred in all patients and the NYHA class improved from grade Ⅳto grade Ⅲin 22 patients(81.5%) in-hospital. Significant differences were noted in the mean BNP and LVEF between pre-PCI and one week post-PCI, BNP[(2699.6±1104.7) pg/ml vs. (737.0 ± 261.7) pg/ml, P<0.05],LVEF[(26.9±5.7)%vs. (36.0±3.41)%, P<0.05)]. No MACE happened in-hospital and at 30-days follow up. Conclusions PCI only to the single-opened vessel lesion among patients with severe left ventricular systolic dysfunction under the condition of limitations to open CTO is safe and can significantly improve clinical outcomes in-hospital and at 30-days follow up, but it must be emphasized that single-opened vessel lesion not with obvious calcification and tortuosity.
