Relationship between adiponectin -11,377C > G Gene polymorphism and risk of coronary heart disease
10.3969/j.issn.1006-5725.2014.15.017
- VernacularTitle:脂联素-11，377C＞G基因多态性与冠心病风险性的关系
- Author:
Jieqi LI
;
Meina JIANG
;
Rongxian ZHANG
;
Hongping YANG
;
Ping LI
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Single nucleotide gene polymorphism;
Case-control study;
Adiponectin
- From:
The Journal of Practical Medicine
2014;(15):2405-2407
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the polymorphism of adiponectin -11 ,377C> G gene and the risk of coronary heart disease(CHD). Methods A total of 126 CHD patients and 130 healthy controls were enrolled and the frequency of each genotypes and allele gene of adiponectin -11 ,377C > G were detected by polymerase chain reaction fragment length polymorphism (PCR-RFLP). Results (1) The adiponectin gene -11,377C > G sites existed gene polymorphism and the three genotypes were GG, CG and CC. (2) There was statistical difference between CHD group and control group; The G allele frequency of CHD group was significantly higher than that in control group (P < 0.05); The frequency of the C allele gene in CHD group was significantly decreased (P < 0.05). (3) There was no statistical difference of frequency distribution of each genotype and allele gene of adiponectin -11,377C > G between acute coronary syndrome (ACS) group and stable angina group . ( 4 ) The risk of CHD were increased in CHD patients with G allele gene of adiponectin-11,377C > G (P < 0.05). Conclusions The polymorphism of adiponectin -11,377C > G is associated with the increased risk of CHD. The increased G allele gene frequency may represent the increased risk of CHD.
