Exercise Preconditioning Improving the Pathological Cardiac Hypertrophy in Pressure Over-loaded Rats
10.3969/j.issn.1000-3614.2014.09.018
- VernacularTitle:运动预处理对压力超负荷诱导的大鼠病理性心肌肥厚的影响
- Author:
Tongyi XU
;
Qingqi HAN
;
Ben ZHANG
;
Dejun GONG
;
Yang YUAN
;
Chengliang CAI
;
Yun DING
;
Liangjian ZOU
- Publication Type:Journal Article
- Keywords:
Exercise preconditioning;
Pressure over-load;
Pathological cardiac hypertrophy;
Transverse aortic constriction
- From:
Chinese Circulation Journal
2014;(9):728-732
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the effect of exercise preconditioning (EP) on pathological cardiac hypertrophy and heart failure (HF) in pressure over-loaded experimental rats.
Methods:A total of 60 SD rats at the age of 6 weeks were randomly divided into 3 groups, n=20 in each group. Sham-operation group, Transverse aortic constriction (TAC) group and EP + TAC group. The cardiac function and structure were evaluated by echocardiography, patholgical changes and HF biomarkers were examined for EP effect at 4 and 8 weeks after TAC.
Results:Compared with Sham-operation group, the cardiac function and structure had obvious changes in the other 2 groups. Compared with TAC group, the ejection fraction in EP+ TAC group increased 15%, the heart weight index and left ventricular weight index decrease 15.7%and 20%respectively at 8 weeks after TAC, all P<0.05. Compared with Sham-operation group, the mRNA and protein expressions of ANP and BNP increased in TAC group at 4 and 8 weeks after TAC, increased in EP+TAC group at 8 week after TAC. Compared with TAC group, the mRNA expressions of ANP and BNP in EP+TAC group decreased 47%and 62%at 4 weeks after TAC, decreased 44%and 28.1%at 8 weeks after TAC, all P<0.05;the protein expression of ANP and BNP in EP+TAC group decreased 22.3%and 48%at 4 weeks after TAC, decreased 21.5%and 38.3%at 8 weeks after TAC, all P<0.01.
Conclusion: EP may improve cardiac pathological hypertrophy in pressure over-loaded rats at the early stage, and delay the heart failure process.
