Expression of STAT3 in children with focal cortical dysplasias type IIIa
10.3969/j.issn.1000-3606.2014.09.015
- VernacularTitle:信号转导与转录活化因子3在儿童颞叶局灶性皮层发育不良IIIa型中的表达
- Author:
Jiangya WANG
;
Wenling LI
;
Jiang WU
;
Yan LOU
- Publication Type:Journal Article
- Keywords:
intractable epilepsy;
astrocytes;
patholgenesis mechanism;
child
- From:
Journal of Clinical Pediatrics
2014;(9):859-862
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To detect the expression of STAT3 in children with FCD (focal cortical dysplasias) type IIIa. Methods The expression of STAT3 and P-STAT3 (ser727) were determined in temporal lobe specimens from 26 children with FCD type IIIa and from 5 normal control by immunohistochemistry, immunolfuorescence and Western blot. Results The expression of P-STAT3 (ser727) was obviously higher in FCD type IIIa than in control group. P-STAT3 (ser727) was located mainly in the nucleus of astrocytes. Conclusions Activated STAT3 might contribute to the patholgenesis of FCD type IIIa by mediating proliferation of astrocytes.
