Changes of serum adiponectin and insulin like growth factor-1 in neonates with hypoxic-ischemic encephalopathy and their clinical significances
10.3969/j.issn.1000-3606.2014.09.008
- VernacularTitle:缺氧缺血性脑病新生儿脂联素、胰岛素样生长因子-1的变化
- Author:
Wei LI
;
Youpeng JIN
;
Zhengyun SUN
- Publication Type:Journal Article
- Keywords:
hypoxic ischemic encephalopathy;
umbilical cord blood;
adiponectin;
insulin like growth factor-1;
neonate
- From:
Journal of Clinical Pediatrics
2014;(9):829-832
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and clinical value of serum insulin like growth factor-1 (IGF-1) and adiponectin in newborns with hypoxic ischemic encephalopathy (HIE). Methods Fifty-two HIE newborns were recruited in this study, including 15 severe, 20 moderate and 17 mild HIE newborns. Twenty healthy newborns were selected as controls. Serum levels of IGF-1 and adiponectin were detected 3-to-5 days (acute period) and 10-to-14 days (recovery period) after birth. Results Serum levels of IGF-1 and adiponectin in the acute period differed signiifcantly among groups of different severity (P<0.05). Serum levels of IGF-1 and adiponectin were decreased with the increase of HIE severity. The level of adiponectin in moderate and severe HIE was lower than that in mild HIE (P<0.05). In recovery period, the level of IGF-1 in severe HIE was lower than that in control (P<0.05). Serum levels of IGF-1 and adiponectin in the acute period was positivity correlated with those in umbilical cord blood of HIE newborns (r=0.531, r=0.611, P<0.01). Conclusions Decreased levels of IGF-l and adiponectin in HIE newborns are correlated with the pathological process of HIE, and can be regarded as indices for severity of HIE. IGF-l and adiponectin is of signiifcance in the clinical diagnosis and prognosis of HIE.
