Relationship between factor-1α and epithelial mesenchymal transformation
10.3760/cma.j.issn.1673-422X.2014.06.005
- VernacularTitle:缺氧诱导因子-1α与上皮间质转化
- Author:
Chun CAO
;
Xiaojie MA
;
Bangxian TAN
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor 1,alpha subunit;
Signal transduction;
Neoplasms;
Epithelial-mesenchymal transformation
- From:
Journal of International Oncology
2014;41(6):415-418
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia inducible factor (HIF-1α) is a hypoxia response regulator,which is highly expressed in malignant tumors.Researches have shown that HIF-1α plays an important role in epithelial mesenchymal transformation.It can regulate epithelial mesenchymal transition through a series of signal pathways and mechanisms at many levels,to participate in the invasion and metastasis of tumors.To explore the mechanism of HIF-lα controlling epithelial mesenchymal transformation has important significance for the development of new,effective tumor treatment methods.
