Expression and significance of Hsa-miR-181a in endometrial carcinoma
10.3969/j.issn.1006-5725.2014.12.012
- VernacularTitle:Hsa-miR-181a在子宫内膜癌变过程中的表达及意义
- Author:
Shuming HE
;
Shumei ZENG
;
Xiuqing CHEN
;
Qiuhong LIANG
- Publication Type:Journal Article
- Keywords:
Endometrial neoplasms;
Hsa-miR-181a;
MicroRNA;
Formalin-fixed paraffin-embedded tissue
- From:
The Journal of Practical Medicine
2014;(12):1895-1897
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of hsa-miR-181a (miR-181a) in can-ceration progression of endometrial carcinoma. Methods A total of 75 formalin-fixed paraffin-embedded tissue specimens were studied in this study , of which , 13 were normal endometrium , 18 were endometrial hyperplasia , 44 were endometrial carcinoma. After total RNA had been extracted , real-time PCR was applied to detect the ex-pression level of miR-181a in endometrial tissue in each group. Results miR-181a expression in formalin-fixed paraffin-embedded tissue specimens can be detected. Expression of miR-181a in endometrial carcinoma was high-er than that in endometrial hyperplasia , its expression in endometrial hyperplasia was also higher than that in normal endometrium, and the difference was statistically significant (P < 0.05). The expression of miR-181a in endometrial carcinoma was associated with FIGO stages (P < 0.05). Conclusion The up-regulation of miR-181a expression in women with endometrial carcinoma may play the role of oncogenes. Abnormal expression of miR-181a is probably associated with the occurrence and development of endometrial carcinoma.
