Protective Effects of (-)-Epigallocatechin Gallate on Daunorubicin-induced Cardiotoxicity in Mice
10.3870/yydb.2014.07.001
- VernacularTitle:表没食子儿茶素没食子酸酯对柔红霉素致小鼠心脏毒性的预防作用
- Author:
Li LI
;
Yanxia TANG
;
Zhiming HUANG
;
Runli CHEN
;
Huandi ZHOU
;
Buming LIU
;
Gang LIANG
- Publication Type:Journal Article
- Keywords:
(-)-Epigallocatechin gallate;
Daunorubicin;
Cardiotoxicity;
Myocardial enzymes
- From:
Herald of Medicine
2014;(7):841-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of (-)-epigallocatechin gallate ( EGCG ) on daunorubicin ( DNR)-induced cardiotoxicity in mice. Methods The qualified mice were randomly divided into four groups:normal control group, myocardial injured model control group,high dose group (80 mg·kg-1 ) and low dose group (40 mg·kg-1 ) of EGCG. EGCG was administered intragastrically once daily for 7 days,followed by a single intraperitoneal injection of DNR (15 mg·kg-1 ) except in the normal control group. The electrocardiogram,myocardial enzymes and TNT-Hs in serum,cardiac ultrastructure of mice were detected after 48 h. Results In DNR model control group,the incidence of arrhythmia was 64. 7%. The activity of serum cardic enzymes including CK,CK-MB,LDH,α-HBDH and ALT,AST, level of TNT-Hs were significantly higher than those in the normal control group(P<0. 01),and myocardial ultrastructure was injured remarkably. The incidence of arrhythmia was 44. 4% in mice treated with high dose of EGCG and 31. 6% in mice with low dose of EGCG. Compared to the model control group, the activity of CK,CK-MB,LDH,α-HBDH and ALT,AST, level of TNT-Hs in serum decreased remarkably in EGCG groups( P<0. 05 or P<0. 01). Low can EGCG alleviated the injury to the ultrastructure of myocardium compared to the model control group. Conclusion EGCG can prevent the cardiac toxicity induced by DNR in mice.
