Molecular biological characteristics of the transcription factor RORγt and the expression in immune-related diseases
- VernacularTitle:转录因子RORγt的分子生物学特征及其在免疫相关性疾病中的表达
- Author:
Zhen WANG
;
Shifu ZHANG
;
Lilan CHENG
- Publication Type:Journal Article
- Keywords:
Transcription factor;
RORγt;
Autoimmune diseases
- From:
Journal of Medical Postgraduates
2014;(6):655-658
- CountryChina
- Language:Chinese
-
Abstract:
RORγt, an immune cell-specific isoform of RORγ( retinoic acid receptor-related orphan nuclear receptor gam-ma) , is a key transcription factor for the development of Th 17 cells both in human and mouse .RORγt is required for the induction of IL-17 transcription and for the manifestation of Th 17-dependent autoimmune diseases in mice .RORγt natural ligands are retinoic acid . RORγt is closely implicated in the pathology of numerous autoimmune diseases , infectious diseases and cancer .With the further re-searches about the role of RORγt, we will clarify the mechanism of RORγt in autoimmune diseases , which will provide new ideas to di-agnose and treat autoimmune diseases .
