Efficacy of Hubei Wingnut(Malus hapehensis) Leaf Decoction on Viral Conjunctivitis Infected with HSV-1
10.3870/yydb.2014.07.006
- VernacularTitle:湖北海棠叶水煎剂对HSV-1病毒性结膜炎治疗作用
- Author:
Zuming LI
;
Lihua KONG
;
Ling YU
;
Qing WANG
;
Chaoming HUANG
;
Zulian XI
;
Keyi QU
;
Jianrong LI
- Publication Type:Journal Article
- Keywords:
Hubei Wingnut ( Malus hapehensis ) leaf;
Conjunctivitis,viral;
Anti-viral effect
- From:
Herald of Medicine
2014;(7):862-865
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of the Hubei Wingnut ( Malus hapehensis ) leaf decoction (MHD) against conjunctivitis infected with human simplex virus type I (HSV-1). Methods Malus hupehcnsis decoction was used as the active treatment and ribavirin ( RBV) eye drop was used as the positive control. Both of the Vero cells and rabbit eye conjunctiva were infected with HSV-1. The effect and mechanism of the MHD on viral replication was determined by observing the cytopathic effect ( CPE) . The efficacy of MHD at different doses on the rabbit viral conjunctivitis was examined by pathological changes of eye conjunctiva tissues. Results MHD did not inhibit the proliferation of HSV-1 in vitro. The inflammatory reactions of rabbit viral conjunctivitis caused by HSV-1 were obviously attenuated or disappeared after treatment with MHD at 6 kg·L-1 and 3 kg·L-1 for 7 consecutive days,compared with the negative control of 0. 9% NaCl. The curative rate of MHD at the middle and high doses was 83. 3% and 100. 0%, respectively. Conclusion MHD has the potential for treating eye conjunctivitis caused by HSV-1 by relieving inflammation.
