Analysis of correlation between polymorphism of Adiponectin gene and ischemic stroke in Xinjiang Uygur and Han nationalities

VernacularTitle:新疆地区维、汉民族缺血性卒中与ADP基因多态性的相关性研究
Author: Zhenzhong ZHANG ; Xiaoying LIANG ; Guangyao Lü ; Hua YAO
Publication Type:Journal Article
Keywords: Ischemic-stroke; Single-nucleotide-polymorphism; Adiponectin
From: Chinese Journal of Immunology 2014;(6):802-807
CountryChina
Language:Chinese
Abstract: Objective:Analysis of two ethnic Uygur and Han investigate ischemic stroke adiponectin (Adiponectin) gene single nucleotide rs182052 , rs6444175 , rs1501296 allele polymorphism point whether the differences.Methods:Gene sequencing methods were used to detect 210 was used cases of acute ischemic stroke patients ( case group ) and 104 healthy people ( control group ) Adiponectin gene ,using case-control association analysis of genotype and allele frequencies compared explore the two ethnic differences in different gene polymorphism loci.Results: When the case group and the control group were compared , it was found that the Adiponectin gene rs64441759G/A was significantly higher in the case group.The risk rate increased significantly to 1.481 times (OR=1.481;95%CI:1.219-1.910; P=0.000).Conclusion: Adiponectin gene rs6444175A allele may be susceptible to pathogenic gene.No significant differences show on the 3 SNP loci of Adiponectin genes between Uygur and Han patients.