IL-17 expression in lesions of oral lichen planus and its auxo-action for chemokine CCL20 expression
10.3969/j.issn.1006-5725.2014.14.013
- VernacularTitle:IL-17在口腔扁平苔藓病损中的表达及其对趋化因子CCL20表达的促进作用
- Author:
Sanxiang XIE
;
Lin FENG
;
Shengrong ZHU
;
Lei DING
- Publication Type:Journal Article
- Keywords:
Oral lichen planus;
CCL20;
IL-17;
Th17
- From:
The Journal of Practical Medicine
2014;(14):2225-2227
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of IL-17, the signature cytokine produced by Th17 cells, in OLP lesion. Methods 24 patients with reticular OLP, 19 patients with atrophic-erosive OLP and 13 healthy volunteers were enrolled in this study . Real-time quantitative PCR ( real-time qPCR ) was performed to analyze the expressions of the production of IL-17 and CCL20 mRNA. Results The expressions of IL-17 mRNA in reticular OLP and atrophic-erosive OLP were significant higher than that in healthy oral mucosa (P = 0.0095, P <0.0001, respectively), meanwhile, remarkable increased IL-17 expression in atrophic-erosive OLP group was found compared with reticular OLP group (P = 0.0012). Additionally, the expressions of CCL20 mRNA in reticular OLP and atrophic-erosive OLP were significant higher than that in control group (P=0.0357, P<0.0001, respectively), meanwhile, CCL20 expression in atrophic-erosive OLP was higher than that in reticular OLP. The expressions of CCL20 mRNA rises with the increased expression of IL-17, and were positive correlated with IL-17 expressions in OLP lesions (P=0.003). Conclusions IL-17 production can induce chemokine CCL20 expression in OLP lesion. The signal pathway may promote the migration and infiltration of inflammatory cells in OLP lesions.
