Level and clinical value of serum cystain C in patients with HBeAg-negative chronic hepatitis B
10.3969/j.issn.1673-4130.2014.13.027
- VernacularTitle:HBeAg 阴性慢性乙型肝炎患者血清胱抑素C水平及其临床价值
- Author:
Xiaoliang WANG
;
Shengyao TANG
;
Guosheng LIU
;
Wei ZHOU
;
Jianqiong ZHENG
;
Fawei ZHOU
- Publication Type:Journal Article
- Keywords:
hepatitis B,chronic;
cysteine proteinase inhibitors;
kidney injury
- From:
International Journal of Laboratory Medicine
2014;(13):1729-1731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change and clinical value of serum cystain C(CysC)level in the patients with HBeAg-negative chronic hepatitis B(CHB).Methods 212 cases of CHB in our hospital were selected and divided into the HBeAg-negative group and the HBeAg-positive group according to the HBeAg status.105 healthy individuals at the same time were enrolled as the control group.The levels of serum CysC,ALT,AST,Cr,BUN and HBV DNA in 3 groups were detected and compared.The corre-lations between serum CysC with AST,AST,Cr,Bun,HBV DNA were analyzed by the Pearson correlation analysis.Results The mean CysC level in the HBeAg-negative group was (1 .40±0.36)mg/L,which was higher than (0.93±0.12)mg/L in the control group and (0.96±0.18)mg/L in the HBeAg-positive group,the differences between them was statistically significant(P <0.05). The CysC was significantly positively correlated with serum Cr level in the HBeAg-negative group(r=0.840,P <0.01).Conclusion The CysC level might be used as an effective index for monitoring the early kidney injury in the patients with HBeAg-negative CHB,which has important significance in the prevention and treatment of HBeAg-negative CHB.
