Inhibitory Effect of Oleanolic Acid on Lipid Accumulation in Cytoplasm of 3T3-L1 Adipocyte
10.11842/wst.2014.06.026
- VernacularTitle:齐墩果酸抑制3T3-L1脂肪细胞脂质堆积
- Author:
Shifeng WANG
;
Chenxi ZHAI
;
Qing LIU
;
Yanling ZHANG
;
Shiyou LI
;
Yanjiang QIAO
- Publication Type:Journal Article
- Keywords:
Oleanolic acid;
3T3-L1 adipocytes;
lipid droplets accumulation
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2014;(6):1353-1358
- CountryChina
- Language:Chinese
-
Abstract:
A collection of 57 natural compounds derived from Chinese herbal medicines were evaluated for their an-ti-adipogenic effects. The lipid droplets in differentiated 3T3-L1 adipocytes treated with tested substrate were de-tected by an image-based assay. The results demonstrated that oleanolic acid (OA) inhibited lipid droplets accumula-tion in 3T3-L1 adipocytes in a dose-dependent manner with the IC50 value of 14.5 μmol·L-1. In addition, ToxInsight assay showed that OA was free of liver injury for HepG2 cells within 60 μmol·L-1. It was concluded that OA, which had an obvious anti-adipogenic effect, can be a candidate for hyperlipidemia therapy.
